Brain Tumours-remaining an area of unmet need

Brain tumours remain one of the most formidable challenges in medical science due to their complex biology, high morbidity, and limited treatment options. Affecting individuals of all ages, these tumours—both malignant and benign—demand urgent and sustained research efforts.

Date: 29 May 2025 | Author: Crista Casey

The Challenge of Brain Tumours

Brain tumours can originate within the brain (primary) or spread from other parts of the body (metastatic). Malignant tumours, such as glioblastomas, are particularly aggressive, while benign tumours, although non-cancerous, can still be life-threatening due to their impact on brain function. Diagnosing brain tumours is challenging due to symptom overlap with other neurological conditions. Although imaging technologies have advanced, early and precise detection remains difficult. Treatments—including surgery, radiation, and chemotherapy—are often limited by tumour location, resistance to therapy, and the need to preserve healthy brain tissue.

Key Statistics:

  • Over 300,000 new cases of brain and central nervous system (CNS) tumours are diagnosed annually worldwide.
  • Glioblastoma has a median survival rate of only 12–15 months.

The Need for Continued Research

Brain tumour research is a critical medical and humanitarian effort. Progress requires collaboration across disciplines—neuroscience, oncology, genomics, and data science. Continued scientific innovation, collaborative research, and strategic investment are key to improving survival rates and quality of life for those affected.

Ongoing research is focused on:

  • Biomarker discovery for earlier and more accurate diagnosis
  • Develop tumour cell targeted therapies
  • Understanding molecular and genetic drivers of tumour growth.
  • Create effective drug delivery systems that bypass the blood-brain barrier.

Promising Areas of Innovation

ImmunotherapyPrecision MedicineAl and Machine
Learning
Minimally Invasive
Techniques
Harnessing the
immune system
to target tumours.
Customising
treatment based
on tumour
genetics.
Improving
diagnostic tools
and treatment
planning
Enhancing
outcomes and
reducing
recovery time

Market Growth and Investment Trends

The brain cancer treatment market is experiencing robust growth, driven by advancements in targeted therapies, immunotherapies, and personalised medicine. Valued at approximately USD 1.9 billion in 2023, the global brain tumour therapeutics market is projected to reach USD 4.2 billion by 2030, reflecting a compound annual growth rate (CAGR) of 10.5%.

  • In the United States, the market is expected to grow from USD 1.25 billion in 2024 to USD 1.87 billion by 2030, at a CAGR of 7.2%. This expansion is fuelled by increased regulatory approvals, such as the FDA’s 2024 approval of a new drug for low-grade diffuse gliomas—the first in over two decades.
  • The European brain tumour treatment market is projected to grow from approximately USD 960 million in 2022 to USD 1.9 billion by 2030, reflecting a compound annual growth rate (CAGR) of 8.9%. This growth is fuelled by factors such as an aging population, increased incidence of high-grade gliomas, and substantial investments in cancer research and healthcare infrastructure across countries like Germany, France, and the UK. Business Market Insights

Brain cancers remain an area of unmet need. Major pharmaceutical companies are actively investing in this space; for instance, Merck’s acquisition of Modifi Biosciences for up to $1.3 billion aims to bolster its brain cancer therapy pipeline. These trends underscore a dynamic investment landscape and a commitment to advancing treatment options for brain cancer patients. However, expanded funding from public and private sectors is essential to support translational research, clinical trials, and emerging technologies. Together, we can drive progress toward more effective treatments—and ultimately, a cure.

About Aixial Group

Since 1999, Aixial has performed more than 1,600 studies across the globe with our teams in APAC, Europe, and North America. Our 1,000+ person team includes multiple oncologists and neurologists and has extensive clinical research experience. Most Aixial team members average 15 years of direct support, management and delivery of clinical trials. Aixial oncology highlights from 306 trials are summarised below. This portfolio includes high-volume enrolment trials with aggressive start-up timelines.

  • 100% oncology experienced team 

This portfolio includes high-volume enrolment trials with aggressive start-up timelines.

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